Mr Eshchar Mizrachi

Research Staff

Research Interests

 

Current research:

• Investigating the underlying interactions between some of the proteins involved in secondary cell wall synthesis in plants.
• High throughput sequencing and de novo assembly of transcriptomes using Solexa technology (Illumina).

Qualifications:

BSc Zoology obtained in the University of Pretoria

Honours-level research project under the supervision of Prof H. Huismans in the field of molecular virology, with the aim of expressing a modified structural protein 7 of African Horsesickness virus as an eGFP fusion protein.

Masters level research project: “The solubility, particle formation and immune display of trimers of major capsid protein 7 of African horsesickness virus fused with enhanced green fluorescent protein”, under the supervision of Prof H. Huismans. The research was aimed at characterizing the properties of a candidate peptide presentation protein and evaluate its viability as a nano-scale subunit vaccine delivery vector.

General interests:

Synthetic Biology
Nanotechnology and its application to biomedical sciences

 

 

Research outputs - Conference presentations

Huismans, H., Mizrachi, E. “The development of a general purpose vaccine display system based on the use of trimers of major capsid protein VP7 of African horsesickness virus”. Oral presentation, Virology Africa 2005 conference, Cape Town, South Africa, December 2005.

Mizrachi, E.; Huismans, H. “The solubility, particle formation and immune display of a modified capsid protein 7 of African horsesickness virus fused with green fluorescent protein.” Oral Presentation, 19th South African Genetics Society (SAGS) Congress, Bloemfontein, South Africa. April 2006.

Huismans, H.; Mizrachi, E.; Meyer, Q.; Rutkowska, D.; Vosloo, W.; Fick, W.C. “Soluble trimers of AHSV VP7, displaying foreign peptides inserted into its top domain, as a general purpose vaccine delivery system”. Oral presentation, 9th International Symposium on Double-Stranded RNA Viruses, Cape town, South Africa, October 2006

Fick, W.; Ratkawska, D.; Mizrachi, E.; Vosloo, W.; Huismans, H. “Soluble trimers of AHSV VP7 as a display system for foreign antigens”. Oral presentation, From Genomes to Protective Antigens – Designing Vaccines Congress, Prague, Czech Republic, November 2006.

 

Mizrachi, E., Ranik, M. and Myburg, A.A. “Cellulose synthase terminal complex morphology: An evolutionary and genetic perspective”. Oral Presentation, 20^th South African Genetics Society Congress, Pretoria, South Africa, March 2008.