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PhD student

Department

FABI
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Primary Supervisor
Dave Berger

Co Supervisor
Dr Shane Murray

My PhD study is focused on using global transcriptome sequencing to identify and exploit the molecular mechanisms at play in the Cercospora zeina – maize pathosystem.  My research interest specifically lies in the defensive molecules that plants produce upon pathogen attack, such as secondary metabolites, and how they contribute to disease resistance.  Phytoalexins are a group of secondary metabolites, synthesised de novo after pathogen attack with antimicrobial properties. My research includes targeted phytoalexin profiling in a resistant and a susceptible maize line in order to characterize the chemical changes that occur in maize leaves in response to C. zeina infection.  The work forms part of a project entitled ‘Genomics of Quantitative Disease Resistance in African Maize Varieties’ a collaborative effort between the University of Pretoria, the Centre for Proteomic and Genomic Research (CPGR), the University of KwaZulu-Natal, and PANNAR SEED (Pty) Ltd. I am based in Cape Town and while a PhD student by night, by day I am a Senior Support and Applications Scientist for Kapa Biosystems, which has recently been acquired by Roche Sequencing.

Congress posters:

  • Meyer J., Van Der Walt AP., Murray, S., Berger, DK. (2014) Applying RNA sequencing to SNP discovery in Maize. SASBi-SAGS JOINT 2012 CONGRESS, Stellenbosch University, Stellenbosch
  • Meyer J., Ntuli J., Wighard S., Berger DK., Murray SL. (2014) Phytoalexins accumulate in maize infected with Cercospora zeina, causal organism of grey leaf spot disease in South Africa. SASBi-SAGS JOINT 2014 CONGRESS, Kwalata Game Lodge, Pretoria

Oral congress presentation:

  • Meyer J., Van Der Walt AP., Murray SL., Berger DK. (2014) RNA-Seq analysis reveals secondary metabolite pathways contributing to Cercospera zeina resistance in maize. South African Society of Biochemistry and Molecular Biology Congress, Goudini Spa, Worcester

 


Export to RIS
Publication
Meyer J, Berger DK, Christensen SA, Murray SL. (2017) RNA-Seq analysis of resistant and susceptible sub-tropical maize lines reveals a role for kauralexins in resistance to grey leaf spot disease, caused by Cercospora zeina. BMC Plant Biology 17:197. 10.1186/s12870-017-1137-9
Christie N, Myburg AA, Joubert F, Murray SL, Carstens M, Lin Y-C, Meyer J, Crampton BG, Christensen SA, Ntuli JF, Wighard SS, Van de Peer Y, Berger DK. (2017) Systems genetics reveals a transcriptional network associated with susceptibility in the maize-gray leaf spot pathosystem. The Plant Journal 89(4):746-763. 10.1111/tpj.13419
Meyer J, Murray SL, Berger DK. (2016) Signals that stop the rot: Regulation of secondary metabolite defences in cereals. Physiological and Molecular Plant Pathology 94:156-166. 10.1016/j.pmpp.2015.05.011 PDF