Dr Jane Chepsergon
Biochemistry, Genetics and Microbiology
There is a molecular battle that takes place during the infection of plants by pathogens. Some of the weapons in the pathogen’s arsenal are known as “effectors;” these are secreted proteins that enter host cells to alter their physiology and suppress the immune system. Effectors can also be a liability for pathogens because potential hosts have evolved ways to recognize these effectors, triggering a defense response leading to localized cell death, preventing the spread of the pathogen. Our research focuses on the identification and characterization of RxLR effectors encoded in the genome of Phytophthora parasitica, the pathogen causing black shank disease in tobacco and root/stem rot in citrus. In addition to contributing to our understanding of the mechanisms of pathogenesis, this study of effectors facilitates breeding for disease-resistant plants, which will decrease agricultural reliance on fungicides.
My Journal Articles
|Chepsergon J, Moleleki LN. (2023) “Order from disordered”: Potential role of intrinsically disordered regions in phytopathogenic oomycete intracellular effector proteins. Current Opinion in Plant Biology 75:102402.
| Chepsergon J, Lucy N Moleleki. (2023) Rhizosphere bacterial interactions and impact on plant health. Current Opinion in Microbiology 73:102297.
|Jane Chepsergon, Celiwe Nxumalo, Brenda Salasini, Aquillah Kanzi, Lucy Moleleki. (2022) Short Linear Motifs (SLiMs) in “Core” RxLR effectors of Phytophthora parasitica var. nicotianae: A case of PpRxLR1 effector. Microbiology Spectrum 10(2)
|Jane Chepsergon, Thabiso E. Motaung, Lucy Novungayo Moleleki. (2021) “Core” RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?. Virulence 12(1):1921-1935.
|Chepsergon J, Motaung TE, Bellieny-Rabelo D, Moleleki LN. (2020) Organize, Don’t Agonize: Strategic Success of Phytophthora Species. Microorganisms 8(6):917.