PROF. Christine Foyer recognized as a Redox Pioneer
|
Dr. Christine Foyer (B.Sc. 1974; Ph.D. 1977) has been recognized as a Redox Pioneer because she has published an article on redox biology that has been cited more than 1000 times, 4 other articles that have been cited more than 500 times, and a further 32 articles that have been each cited more than 100 times. During her Ph.D. at the Kings College, University of London, United Kingdom, Dr. Foyer discovered that ascorbate and glutathione and enzymes linking NADPH, glutathione, and ascorbate are localized in isolated chloroplast preparations. These observations pioneered the discovery of the ascorbate-glutathione cycle, now known as Foyer-Halliwell-Asada pathway after the names of the three major contributors, a crucial mechanism for H2O2 metabolism in both animals and plants. Dr. Foyer has made a very significant contribution to our current understanding of the crucial roles of ascorbate and glutathione in redox biology, particularly in relation to photosynthesis, respiration, and chloroplast and mitochondrial redox signaling networks. Antioxid. Redox Signal. 15, 2383 – 2391. My view is that science...is compulsive and you have to keep with it all the time and not get despondent when things do not work well. Being passionate about science is what carries you through the hard times so that it isn't so much work, as a hobby that you do for a living. It is the thrill of achieving a better understanding and finding real pleasure in putting new ideas together, explaining data and passing on knowledge that keeps you going no matter what!
|
Biotechnology and Entrepreneurship at University of Pretoria |
An all-female team of young entrepreneurship students has won the first ever Biotechnology in the Workplace competition at the University of Pretoria on the weekend of November 12th – 14th, 2010. The competition was the culmination of an Honours course designed to teach students about entrepreneurship in the biological sciences. After an intensive weekend of seminars and mentoring sessions with South African and international entrepreneurship experts, four groups of students competed by pitching their business plans to an independent panel of " investors " . The winning team of Degracious Kgoale (Research and Development Director), Lindiwe Nkosi (Marketing Director), Monique Heystek (Finance Director) and Magdeleen du Plessis (Managing Director), with Prof. Karl Kunert.
" Fruit Loot, " the winning hypothetical company, was an agricultural biotech firm targeting the fruit growing market of South Africa. Their key product " Branchstop " was a biologically produced strigolactone spray which could be applied to trees to stop excessive lateral branching, thereby increasing the fruit yield of orchard trees up to 80%. The company had a strong intellectual property portfolio and an impressive marketing strategy targeting their customer base through print ads and fruit growers' unions. The presented business pitch included a realistic financial plan, expansion routes and exit strategies which convinced the judging panel. The winning team presented their convincing business plan with great enthusiasm. They showed good teamwork during the workshop and were a strong unit which handled the rigorous questions of the judges very well.
The winning group is pictured with Professor Karl Kunert (Univ Pretoria) who organised the honours module on Biotechnology in the Workplace in conjunction with Prof Jonathan Youngelson (Head of Innovation Support). The entrepreneurship weekend was supported by the British Council, in collaboration with the John Innes Centre, Norwich UK.
_______________________________________________________________________________
|
Visit to Chonbuk National University in Jeonju, South Korea, March 2009 |
MPP - News
New Publications
Chepsergon J, Moleleki LN. (2023) “Order from disordered”: Potential role of intrinsically disordered regions in phytopathogenic oomycete intracellular effector proteins. Current Opinion in Plant Biology 75:102402.
10.1016/j.pbi.2023.102402
Macharia TN, Duong TA, Moleleki LN. (2023) n silico secretome analyses of the polyphagous root-knot nematode Meloidogyne javanica: a resource for studying M. javanica secreted proteins. BMC Genomics 24:296.
10.1186/s12864-023-09366-6
Chepsergon J, Lucy N Moleleki. (2023) Rhizosphere bacterial interactions and impact on plant health. Current Opinion in Microbiology 73:102297.
10.1016/j.mib.2023.102297
Jane Chepsergon, Celiwe Nxumalo, Brenda Salasini, Aquillah Kanzi, Lucy Moleleki. (2022) Short Linear Motifs (SLiMs) in “Core” RxLR effectors of Phytophthora parasitica var. nicotianae: A case of PpRxLR1 effector. Microbiology Spectrum 10(2)
10.1128/spectrum.01774-21
Maphosa S and Moleleki LN. (2021) Isolation and Characterization of Outer Membrane Vesicles of Pectobacterium brasiliense 1692. Microorganisms 9:1-20.
10.3390/ microorganisms9091918
Jane Chepsergon, Thabiso E. Motaung, Lucy Novungayo Moleleki. (2021) “Core” RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?. Virulence 12(1):1921-1935.
10.1080/21505594.2021.1948277
Collins Kipngetich Tanui, Divine Yutefar Shyntum, Precious K. Sedibane, Daniel Bellieny-Rabelo, Lucy N. Moleleki. (2021) Pectobacterium brasiliense 1692 chemotactic responses and the role of methyl-accepting chemotactic proteins in ecological fitness. 12
10.3389/fpls.2021.650894 

Teresia N. Macharia, Daniel Bellieny-Rabelo, Lucy N. Moleleki. (2020) Transcriptome Profiling of Potato (Solanum tuberosum L.) Responses to Root-Knot Nematode (Meloidogyne javanica) Infestation during A Compatible Interaction.
10.3390/microorganisms8091443
Chepsergon J, Motaung TE, Bellieny-Rabelo D, Moleleki LN. (2020) Organize, Don’t Agonize: Strategic Success of Phytophthora Species. Microorganisms 8(6):917.
10.3390/microorganisms8060917
Shin G, Schacterle JK, Shyntum DY, Moleleki LN, Coutinho T, Sundin GW. (2019) Functional characterization of a global virulence regulator Hfq and identification of Hfq-dependent sRNAs in the plant pathogen Pantoea ananatis. Frontiers in Microbiology 10:1-19.
10.3389/fmicb.2019.02075
Shutt VM, Shin G, van der Waals JE, Goszczynska T, Coutinho T. (2018) Characterization of Ralstonia strains infecting tomato plants in South Africa. Crop Protection 112:56-62.
10.1016/j.cropro.2018.05.013
Siphathele Sibanda, Stanford Kwenda, Collins K. Tanui, Divine Shyntum, Teresa Coutinho, Lucy Moleleki. (2018) Transcriptome profiling reveals the EanI/R quorum sensing regulon in Pantoea ananatis LMG 2665T. Genes 9(3):148.
10.3390/genes9030148
Siphathele Sibanda, Lucy Moleleki, Divine Shyntum, Teresa Coutinho. 2018. Quorum Sensing in Gram-Negative Plant Pathogenic Bacteria. In: Advances in Plant Pathology. Intechopen., London SE1 9SG, United Kingdom, pp 67-89.
Tanui CK, Shyntum DY, Priem SL, Theron J, Moleleki LN. (2017) Influence of the ferric uptake regulator (Fur) protein on pathogenicity in Pectobacterium carotovorum subsp. brasiliense. Plos One 5(12)
10.1371/journal.pone.0177647
Gorshkov V, Kwenda S, Petrova O, Osipova E, Gogolev Y, Moleleki LN. (2017) Global Gene Expression Analysis of Cross-Protected Phenotype of Pectobacterium atrosepticum. PLoS ONE 12(1)
10.1371/journal.pone.0169536
Weller-Stuart T, Toth I, De Maayer P, Coutinho T. (2017) Swimming and twitching motility are essential for attachment and virulence of Pantoea ananatis in onion seedlings. Molecular Plant Pathology 18(5):734-745.
10.1111/mpp.12432
Kwenda S, Motlolometsi TV, Birch PRJ, Moleleki LN. (2016) RNA-seq profiling reveals defense responses in a tolerant potato cultivar to stem infection by Pectobacterium carotovorum ssp. brasiliense. Frontiers in Plant Science 7(1905)
10.3389/fpls.2016.01905
Kwenda S, Birch PRJ, Moleleki LN. (2016) Genome-wide identification of potato long intergenic noncoding RNAs responsive to Pectobacterium carotovorum subspecies brasiliense infection. BMC Genomics 17(614)
10.1186/s12864-016-2967-9
Sibanda S, Theron J, Shyntum DY, Moleleki LN, Coutinho TA. (2016) Characterization of two LuxI/R homologs in Pantoea ananatis LMG 2665 T. Canadian Journal of Microbiology 62(11):893-903.
10.1139/cjm-2016-0143
Moleleki LN, Pretorius RG, Tanui CK, Mosina G, Theron J. (2016) A quorum sensing‐defective mutant of Pectobacterium carotovorum subsp. brasiliense 1692 is attenuated in virulence and unable to occlude xylem tissue of susceptible potato plant stems. Molecular Plant Pathology
10.1111/mpp.12372