Plant secondary cell wall ultrastructure and its associated modifications contributes to the resistance of wood to industrial bioprocessing. To effectively mitigate these limitations, recent advancements in genetic engineering have presented novel avenues such as CRISPR, which have the potential to significantly improve bio-refinery efficiency. My work thus takes advantage of CRISPR and related novel gene editing techniques, to genetically manipulate cell wall-associated genes to generate plants with easier-to-deconstruct cell walls, therefore eliminating the need and associated cost of bioprocessing, while maintaining high wood biomass yield.